Michael P. D'Alessandro, M.D.
Peer Review Status: Internally Peer Reviewed
Etiology/Pathophysiology:
Etiology unknown. Due to abnormal proliferation of histiocytes
throughout the reticuloendothelial system. Multi system organ
involvement with 80% having skeletal lesions. Variable prognosis.
Pathology:
Not applicable
Imaging Findings:
On plain film more commonly have well defined medullary lesions with
or without sclerotic margins that may have associated bone expansion,
cortical destruction, periosteal reaction, soft tissue mass, and
pathologic fracture.
Bone scan is useful in evaluating the disseminated form of the disease and the lesions are hot on it.
DDX:
References:
See References Chapter.
See related Provider Topics Bone Cancer, Bones, Joints and Muscles or Cancers.
See related Patient Topics Bones, Joints and Muscles or Cancers.
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