Michael P. D'Alessandro, M.D.
Peer Review Status: Internally Peer Reviewed
Etiology/Pathophysiology:
A hamartomatous proliferation of fibrous and connective tissue in the
brain, skin, skeleton, kidneys, and heart.
Pathology:
The hamartomatous lesions in the brain consist of proliferating glial
tissue and ganglion cells.
Imaging Findings:
The intracranial tubers are usually calcified and usually are in a
periventricular / subependymal location but they can occasionally be
found in the brain parenchyma. The tubers may undergo malignant
degeneration into giant cell astrocytomas.
DDX:
References:
See References Chapter.
See related Provider Topics Brain and Nervous System, Genetics/Birth Defects or Tuberous Sclerosis.
See related Patient Topics Brain and Nervous System or Genetics/Birth Defects.
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